Intrinsically unstructured proteins and neurodegenerative diseases: Conformational promiscuity at its best
نویسندگان
چکیده
منابع مشابه
The Role of Intrinsically Unstructured Proteins in Neurodegenerative Diseases
The number and importance of intrinsically disordered proteins (IUP), known to be involved in various human disorders, are growing rapidly. To test for the generalized implications of intrinsic disorders in proteins involved in Neurodegenerative diseases, disorder prediction tools have been applied to three datasets comprising of proteins involved in Huntington Disease (HD), Parkinson's disease...
متن کاملNeurodegenerative Diseases: Multifactorial Conformational Diseases and Their Therapeutic Interventions
Neurodegenerative diseases are multifactorial debilitating disorders of the nervous system that affect approximately 30 millionindividuals worldwide. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis diseases are the consequence of misfolding and dysfunctional trafficking of proteins. Beside that, mitochondrial dysfunction, oxidative st...
متن کاملThe interplay between structure and function in intrinsically unstructured proteins.
Intrinsically unstructured proteins (IUPs) are common in various proteomes and occupy a unique structural and functional niche in which function is directly linked to structural disorder. The evidence that these proteins exist without a well-defined folded structure in vitro is compelling, and justifies considering them a separate class within the protein world. In this paper, novel advances in...
متن کاملIntrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders
Vladimir N. Uversky* 1 Department of Molecular Medicine, USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA 2 Biology Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia 3 Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Russia 4 Laboratory of Structural Dynamics, S...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2011
ISSN: 1521-6543
DOI: 10.1002/iub.498